OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 6h03
Q-score: 0.156
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ Pubmed: 30552328 DOI: doi:10.1038/s41467-018-07653-5 ]
- C6 (Complex from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- Complement component c8 beta chain (61 kDa, Protein from Human)
- C5b (Complex from Homo sapiens)
- Complement component c8 gamma chain (20 kDa, Protein from Human)
- Complement component c6 (102 kDa, Protein from Human)
- Complement component c8 alpha chain (61 kDa, Protein from Human)
- Complement component c9 (61 kDa, Protein from Human)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- Complement c5,complement c5 (177 kDa, Protein from Human)
- Complement component c7 (91 kDa, Protein from Human)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- C8 gamma (Complex from Homo sapiens)
- C7 (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
Closed conformation of the Membrane Attack Complex
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 6h04
Q-score: 0.179
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ Pubmed: 30552328 DOI: doi:10.1038/s41467-018-07653-5 ]
- C6 (Complex from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- Complement component c8 beta chain (61 kDa, Protein from Human)
- C5b (Complex from Homo sapiens)
- Complement component c8 gamma chain (20 kDa, Protein from Human)
- Complement component c6 (102 kDa, Protein from Human)
- Complement component c8 alpha chain (61 kDa, Protein from Human)
- Complement component c9 (61 kDa, Protein from Human)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- Complement c5,complement c5 (177 kDa, Protein from Human)
- Complement component c7 (91 kDa, Protein from Human)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- C8 gamma (Complex from Homo sapiens)
- C7 (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
Asymmetric region of the Membrane Attack Complex in the closed conformation
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ Pubmed: 30552328 DOI: doi:10.1038/s41467-018-07653-5 ]
- C6 (Complex from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- C7 (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
Consensus map of the Membrane Attack Complex
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ Pubmed: 30552328 DOI: doi:10.1038/s41467-018-07653-5 ]
- C6 (Complex from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- C7 (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
Asymmetric region of the Membrane Attack Complex in the open conformation
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ Pubmed: 30552328 DOI: doi:10.1038/s41467-018-07653-5 ]
- C6 (Complex from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- C7 (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
Hinge region of the Membrane Attack Complex in the open conformation
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ Pubmed: 30552328 DOI: doi:10.1038/s41467-018-07653-5 ]
- C6 (Complex from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- C7 (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
C9 oligomer region of the Membrane Attack Complex in the open conformation
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ Pubmed: 30552328 DOI: doi:10.1038/s41467-018-07653-5 ]
- C9 (Complex from Homo sapiens)
- Membrane attack complex (690 kDa, Complex from Homo sapiens)
Molecular basis of human kinesin-8 function and inhibition
Resolution: 5.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 5oam
Q-score: 0.255
Locke J, Joseph AP, Pena A, Mockel MM, Mayer TU, Topf M, Moores CA
PNAS (2017) 114 pp. E9539-E9548 [ Pubmed: 29078367 DOI: doi:10.1073/pnas.1712169114 ]
- Tubulin, alpha (Complex from Bos taurus)
- Tubulin alpha chain (50 kDa, Protein from Bovine)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Kinesin-like protein kif18a (42 kDa, Protein from Homo sapiens)
- 13-protofilament microtuble-bound human kinesin-8 motor domain neck-linker without nucleotide (Complex)
- Magnesium ion (24 Da, Ligand)
- Tubulin beta chain (49 kDa, Protein from Pig)
- Tublin, beta (Complex from Sus scrofa)
- Taxol (853 Da, Ligand)
- Kinesin-8 motor domain neck-linker (Complex from Homo sapiens)
Molecular basis of human kinesin-8 function and inhibition
Resolution: 5.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 5ocu
Q-score: 0.26
Locke J, Joseph AP, Pena A, Mockel MM, Mayer TU, Topf M, Moores CA
PNAS (2017) 114 pp. E9539-E9548 [ Pubmed: 29078367 DOI: doi:10.1073/pnas.1712169114 ]
- Tubulin, alpha (Complex from Bos taurus)
- Tubulin alpha chain (50 kDa, Protein from Bovine)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Tubulin, beta (Complex from Sus scrofa)
- 13-protofilament microtuble-bound human kinesin-8 motor domain neck-linker with amppnp (Complex)
- Zinc ion (65 Da, Ligand)
- Kinesin-like protein kif18a (42 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Tubulin beta chain (49 kDa, Protein from Pig)
- Taxol (853 Da, Ligand)
- Kinesin-8 motor domain neck-linker (Complex from Homo sapiens)
Molecular basis of human kinesin-8 function and inhibition
Locke J, Joseph AP, Pena A, Mockel MM, Mayer TU, Topf M, Moores CA
PNAS (2017) 114 pp. E9539-E9548 [ Pubmed: 29078367 DOI: doi:10.1073/pnas.1712169114 ]
- Tubulin alpha chain (50 kDa, Protein from Bovine)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Kinesin-like protein kif18a (42 kDa, Protein from Homo sapiens)
- 4-chloranyl-2-nitro-1-(phenylsulfonyl)benzene (297 Da, Ligand)
- Tubulin beta chain (Complex from sus scrofa)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tubulin alpha chain (Complex from Bos taurus)
- Zinc ion (65 Da, Ligand)
- 13-protofilament microtuble-bound human kinesin-8 motor domain neck-linker with its specific inhibitor btb-1 (Complex)
- Magnesium ion (24 Da, Ligand)
- Tubulin beta chain (49 kDa, Protein from Pig)
- Taxol (853 Da, Ligand)
- Kinesin-8 motor domain neck-linker (Complex from Homo sapiens)